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Source: http://the-gadgeteer.com/2013/03/18/deal-of-the-day-7-android-4-0-2gb-tablet-reader/
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Chinese soldiers march outside the Great Hall of the People before the closing ceremony of the National People's Congress in Beijing, China, Sunday, March 17, 2013. (AP Photo/Alexander F. Yuan)
Chinese soldiers march outside the Great Hall of the People before the closing ceremony of the National People's Congress in Beijing, China, Sunday, March 17, 2013. (AP Photo/Alexander F. Yuan)
BEIJING (AP) ? China's new premier says his government is committed to strong relations with the U.S. and sees a strong outlook for trade and investment between the sides.
Li Keqiang told reporters at a Sunday news conference that despite their differences, conflict between the world's first and second largest economies is not inevitable. China's new leaders "attach great importance" to relations with the U.S. and will work with Barack Obama's administration to move ties into a new stage, Li said.
Two-way trade hit almost $500 billion last, although disputes linger over Chinese trade practices, opposition to Chinese investment in the U.S. and complaints over alleged Chinese computer hacking.
Li was speaking in his first news conference since being appointed premier last week with primary responsibility for running the Chinese economy.
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For the first time, scientists have transplanted neural cells derived from a monkey's skin into its brain and watched the cells develop into several types of mature brain cells, according to the authors of a new study in Cell Reports. After six months, the cells looked entirely normal, and were only detectable because they initially were tagged with a fluorescent protein.
Because the cells were derived from adult cells in each monkey's skin, the experiment is a proof-of-principle for the concept of personalized medicine, where treatments are designed for each individual.
And since the skin cells were not "foreign" tissue, there were no signs of immune rejection ? potentially a major problem with cell transplants. "When you look at the brain, you cannot tell that it is a graft," says senior author Su-Chun Zhang, a professor of neuroscience at the University of Wisconsin-Madison. "Structurally the host brain looks like a normal brain; the graft can only be seen under the fluorescent microscope."
Marina Emborg, an associate professor of medical physics at UW-Madison and the lead co-author of the study, says, "This is the first time I saw, in a nonhuman primate, that the transplanted cells were so well integrated, with such a minimal reaction. And after six months, to see no scar, that was the best part."
The cells were implanted in the monkeys "using a state-of-the-art surgical procedure" guided by an MRI image, says Emborg. The three rhesus monkeys used in the study at the Wisconsin National Primate Research Center had a lesion in a brain region that causes the movement disorder Parkinson's disease, which afflicts up to 1 million Americans. Parkinson's is caused by the death of a small number of neurons that make dopamine, a signaling chemical used in the brain.
The transplanted cells came from induced pluripotent stem cells (iPS cells), which can, like embryonic stem cells, develop into virtually any cell in the body. iPS cells, however, derive from adult cells rather than embryos.
In the lab, the iPS cells were converted into neural progenitor cells. These intermediate-stage cells can further specialize into the neurons that carry nerve signals, and the glial cells that perform many support and nutritional functions. This final stage of maturation occurred inside the monkey.
Zhang, who was the first in the world to derive neural cells from embryonic stem cells and then iPS cells, says one key to success was precise control over the development process. "We differentiate the stem cells only into neural cells. It would not work to transplant a cell population contaminated by non-neural cells."
Another positive sign was the absence of any signs of cancer, says Zhang ? a worrisome potential outcome of stem cell transplants. "Their appearance is normal, and we also used antibodies that mark cells that are dividing rapidly, as cancer cells are, and we do not see that. And when you look at what the cells have become, they become neurons with long axons [conducting fibers], as we'd expect. They also produce oligodendrocytes that are helping build insulating myelin sheaths for neurons, as they should. That means they have matured correctly, and are not cancerous."
The experiment was designed as a proof of principle, says Zhang, who leads a group pioneering the use of iPS cells at the Waisman Center on the UW-Madison campus. The researchers did not transplant enough neurons to replace the dopamine-making cells in the brain, and the animal's behavior did not improve.
Although promising, the transplant technique is a long way from the clinic, Zhang adds. "Unfortunately, this technique cannot be used to help patients until a number of questions are answered: Can this transplant improve the symptoms? Is it safe? Six months is not long enough? And what are the side effects? You may improve some symptoms, but if that leads to something else, then you have not solved the problem."
Nonetheless, the new study represents a real step forward that may benefit human patients suffering from several diseases, says Emborg. "By taking cells from the animal and returning them in a new form to the same animal, this is a first step toward personalized medicine."
The need for treatment is incessant, says Emborg, noting that each year, Parkinson's is diagnosed in 60,000 patients. "I'm gratified that the Parkinson's Disease Foundation took a risk as the primary funder for this small study. Now we want to move ahead and see if this leads to a real treatment for this awful disease."
"It's really the first-ever transplant of iPS cells from a non-human primate back into the same animal, not just in the brain," says Zhang. "I have not seen anybody transplanting reprogrammed iPS cells into the blood, the pancreas or anywhere else, into the same primate. This proof-of-principle study in primates presents hopes for personalized regenerative medicine."
###
University of Wisconsin-Madison: http://www.wisc.edu
Thanks to University of Wisconsin-Madison for this article.
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Source: http://www.labspaces.net/127310/Transplanted_brain_cells_in_monkeys_light_up_personalized_therapy
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DEAR ABBY: I have been married 30 years and have raised four children to adulthood. I recently found out my husband has been having an affair with a prostitute from a strip club. He paid all her living expenses and promised to marry her. She was 26 when it started; he is 56. He told her his wife had run away with another man and that he was divorced. When I confronted him, he lied, lied, lied.He wants to continue living together and pretend nothing happened. He went to counseling and quit. Then he went to a psychiatrist, who diagnosed him with a "mixed personality disorder. ...
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Oscar Niemeyer, one of the world?s most prominent modern architects, is re??nowned for his light, airy and fanciful structures. Famous for designing the capital city of Bras?lia, and for collaborating with Le Corbusier on the United Nations headquarters in New York, Niemeyer was a pioneer in curving concrete and giant, graceful arches. The Brazilian architect died last year in Rio de Janeiro at age 104.
EL: You?re the first leader in the creative arts we?ve interviewed, and the first who is not from North America.
Niemeyer: I am honored.
EL: You found beauty in reinforced concrete. How?
Niemeyer: Strength and beauty may coexist. I believe not that ?form follows function,? but that ?form follows beauty.? My work follows the liberated, sensual curves of the mountains of my country, in the sinuousness of its rivers, in the waves of the ocean, and on the body of the beloved woman. Surprise and enchantment are my goals.
EL: There?s a story from when you were a young assistant in 1936, helping prepare drawings for a ministry in Rio. Didn?t Le Corbusier come to visit and ?
Niemeyer: I decided to make some sketches based on his. Corbu had de??signed glass to the ground and concrete shades. I devised a passageway and generally streamlined the shapes. They came and asked to see my drawings, and not wanting to interfere, I threw them out the window. They sent someone to fetch them, and liked what I did.
EL: Your work is described as jaunty and uplifting, aware of light and moun??tains, sea and sky.
Niemeyer: Corbu once said that I had Rio?s mountains in my eyes. I laughed.
EL: A fascist regime ruled Brazil for 21 years, most of which you spent in Europe. Until your exit, you had been very practical about working with the government. What made you go?
Niemeyer:? I was in Lisbon in 1964 when I heard that the Brazilian military, backed by the United States, had overthrown the government. They ransacked my studio. When I got home, they interrogated me. But I stayed for a few years. Little by little, I felt the pressure against me growing. They rejected my airport design and tore down a school I built. When an army officer told me I would be arrested the next day, I left for Paris.
EL: You stayed away until 1985. During that time, you produced some of your best work, including a headquarters for the Mondadori publishing house in Italy and two major buildings in France. You also visited the Soviet Union. Didn?t the public architecture there make you grind your teeth?
Niemeyer: Yes. I told them, ?On the politics, I?m with you. But your architecture is awful. Look, I didn?t come here to criticize, but you asked. It?s terrible.?
EL: After you came back to Rio, you picked right up, designing stadiums and an art museum that looks like a flying saucer.
Niemeyer: We absolutely need to look at the sky and feel how insignificant we are?the offspring of nature.
EL: People still marvel at your ability to complete public works under adverse conditions.
Niemeyer: I have said it before and I will tell you: The ultimate task of a leader is to dream. Otherwise, things don?t happen.
Sources: The New York Times Magazine; The Economist, Museu Oscar Niemeyer.
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The Highway 412 lane expansion project from Washington Avenue to State Line Road in Siloam Springs expanded the road from four to six lanes. But now there is a median that some say is preventing drivers from turning left directly into businesses.
City officials and business owners say the median prevents drivers from having direct access to businesses on the opposite side so, drivers have to make a U-turn to get where they need to go.
?There are approximately 117 businesses in that area that are affected immediately by this median,? said Holland Hayden, City of Siloam Springs Director of Communications.
Some businesses say they?re seeing fewer customers because getting there isn?t convenient for drivers.
?Usually people can turn in this way but they can`t turn in that way because they have to go all the way to the stoplight and turn around so it`s hard for business,? said A.J Yoeum, Shipley Donuts.
Several businesses are affected.
?Kind of slow down a lot because people have to turn around and they don?t like it,? added Dong Tran at Lee?s Nails.
The Arkansas State Highway and Transportation Department expanded the section of Highway 412 from four to six lanes because of increased traffic.
The state reported a traffic increase from 14,000 vehicles in 1986 to 28,000 in 2005 when the study was conducted.
The median is there for several safety reasons and previously that section of Highway 412 was not access controlled.
Officials said there are many driveways to businesses from the highway along that stretch which results in a high number of left turns.
With the increasing volume of traffic and the recent expansion left turns need to be controlled for safety and efficient moving traffic, which is the purpose of the median, according to officials.
Hayden said during the planning phases there were several public meetings where residents and business owners were able to express concerns.
?Because we knew that it was going to really affect the town and businesses in Siloam Springs we tried to offer a lot of different solutions.? However at the end of the day we didn?t have much say to it.?
State officials say 34 percent of those who attended the meetings supported the improvements which included the median.
And some say it`s just going to take time for people to get used to making a U-turns.
?It took them awhile to realize hey it is legal to make a U-turn, they would say ?we can`t get there anymore,? and I would say ?no it?s legal, just go to the stoplight turn around and come back,?? said Sylvia Burnett, head waitress at Callahan?s Steak House.
The state is currently in the design phases on continuing the expansion project east of Washington Avenue.
The project was funded by the American Recovery and Reinvestment Act of 2009.
Source: http://5newsonline.com/2013/03/12/businesses-say-median-strip-hurting-sales/
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Contact: Sigmund Gr?nmo
sigmund.gronmo@rektor.uib.no
47-555-82002
The University of Bergen
The Board of the Ludvig Holberg Memorial Fund has decided to award the 2013 Holberg International Memorial Prize to anthropologist and sociologist Bruno Latour. The Prize amount is NOK 4.5 million (EUR 610,000/USD 790,000). The 2013 Nils Klim Prize is awarded to Norwegian economist Ingvild Alms. The Prize amount is NOK 250,000 (EUR 34,000/USD 43,000).
Chairman of the Ludvig Holberg Memorial Fund, Sigmund Grnmo, announced the winners in Bergen, Norway, today, 13 March. The Prize winners will receive the prizes at an award ceremony in Hkonshallen in Bergen, Norway on 5 June 2013.
Questions the natural sciences' production of knowledge
French anthropologist and sociologist Bruno Latour has been described by the Holberg Prize Academic Committee as a creative, humorous and unpredictable researcher. The Academic Committee justifies the award for this year's Holberg Prize by stating that "Bruno Latour has undertaken an ambitious analysis and reinterpretation of modernity, and has challenged fundamental concepts such as the distinction between modern and pre-modern, nature and society, human and non-human. ()The impact of Latour's work is evident internationally and far beyond studies of the history of science, art history, history, philosophy, anthropology, geography, theology, literature and law." Latour is currently Professor at Sciences Po in Paris.
Laboratory life (1979), authored with Steven Woolgar, was the first of a number of pioneering publications that have set the standard for ethnographic analyses of the making of scientific facts. In We have never been modern (1991) Latour questions the absolute division between nature and society, a division that several phenomena in our age, such as e.g. biotechnology, climate change and the HIV/AIDS epidemic, make it difficult to maintain. He claims that this is a division that has never existed in an absolute form and proposes radical new ways of facing this reality.
A strong, public voice
In the 1980s Latour, together with colleagues Michel Callon and John Law, developed the "Actor Network Theory" (ANT) as a method. The basic premise is that society consists of a network of actors, where all actors influence and are influenced by the network and each other. His involvement in museum science, aesthetics and the use of digital techniques in the humanities led to spectacular museum exhibitions Iconoclash (2002) and Making Things Public (2005) which sparked debate and involvement around subjects related to knowledge and freedom of information.
Since the late 1990s Latour has been involved in the discourse on environmental challenges and climate change, which led to the book Politics of Nature (1999). Here he argues that when modernization has progressed so far that nature rebels, it is time to "ecologize" rather than "modernize". In his latest book Inquiry into Modes of Existence An Anthropology of the Modern (2012) he pursues this debate further and also launches a digital online counterpart, http://www.modesofexistence.org, where others may contribute to research.
Ingvild Alms - new methods for measuring inequality
Ingvild Alms is a Norwegian economist who in just a few years has become established as a leading international researcher. She is currently employed as associate professor at the Norwegian School of Economics in Bergen, where she researches the measuring of inequalities in income and what is perceived as justifiable differences in terms of inequalities in income. In addition to covering a wide field of research and publishing articles in leading scientific journals, she actively participates in social debate.
Alms' doctoral thesis "Essays in Economic Inequality" (2008) aroused much attention both in Norway and internationally. One of the essays was published in world-leading journal American Economics Review, which made her the first Nordic woman to publish a single-authored paper in that journal. The article demonstrated a new method for measuring international inequalities and criticised existing methods for major weaknesses that have led income levels in certain countries, for example China, to being overrated.
###
Our website presents the academic committee's statement, interviews, texts, pictures, etc., on the prize winners: http://www.holbergprisen.no/en
Press contacts:
Information about the prizes and the announcement:
Professor Sigmund Grnmo
Chair of the Ludvig Holberg Memorial Fund
Press contact in US:
Professor Michael Lynch
Cornell University
M: 1-607-266-7063
mel27@cornell.edu
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Contact: Sigmund Gr?nmo
sigmund.gronmo@rektor.uib.no
47-555-82002
The University of Bergen
The Board of the Ludvig Holberg Memorial Fund has decided to award the 2013 Holberg International Memorial Prize to anthropologist and sociologist Bruno Latour. The Prize amount is NOK 4.5 million (EUR 610,000/USD 790,000). The 2013 Nils Klim Prize is awarded to Norwegian economist Ingvild Alms. The Prize amount is NOK 250,000 (EUR 34,000/USD 43,000).
Chairman of the Ludvig Holberg Memorial Fund, Sigmund Grnmo, announced the winners in Bergen, Norway, today, 13 March. The Prize winners will receive the prizes at an award ceremony in Hkonshallen in Bergen, Norway on 5 June 2013.
Questions the natural sciences' production of knowledge
French anthropologist and sociologist Bruno Latour has been described by the Holberg Prize Academic Committee as a creative, humorous and unpredictable researcher. The Academic Committee justifies the award for this year's Holberg Prize by stating that "Bruno Latour has undertaken an ambitious analysis and reinterpretation of modernity, and has challenged fundamental concepts such as the distinction between modern and pre-modern, nature and society, human and non-human. ()The impact of Latour's work is evident internationally and far beyond studies of the history of science, art history, history, philosophy, anthropology, geography, theology, literature and law." Latour is currently Professor at Sciences Po in Paris.
Laboratory life (1979), authored with Steven Woolgar, was the first of a number of pioneering publications that have set the standard for ethnographic analyses of the making of scientific facts. In We have never been modern (1991) Latour questions the absolute division between nature and society, a division that several phenomena in our age, such as e.g. biotechnology, climate change and the HIV/AIDS epidemic, make it difficult to maintain. He claims that this is a division that has never existed in an absolute form and proposes radical new ways of facing this reality.
A strong, public voice
In the 1980s Latour, together with colleagues Michel Callon and John Law, developed the "Actor Network Theory" (ANT) as a method. The basic premise is that society consists of a network of actors, where all actors influence and are influenced by the network and each other. His involvement in museum science, aesthetics and the use of digital techniques in the humanities led to spectacular museum exhibitions Iconoclash (2002) and Making Things Public (2005) which sparked debate and involvement around subjects related to knowledge and freedom of information.
Since the late 1990s Latour has been involved in the discourse on environmental challenges and climate change, which led to the book Politics of Nature (1999). Here he argues that when modernization has progressed so far that nature rebels, it is time to "ecologize" rather than "modernize". In his latest book Inquiry into Modes of Existence An Anthropology of the Modern (2012) he pursues this debate further and also launches a digital online counterpart, http://www.modesofexistence.org, where others may contribute to research.
Ingvild Alms - new methods for measuring inequality
Ingvild Alms is a Norwegian economist who in just a few years has become established as a leading international researcher. She is currently employed as associate professor at the Norwegian School of Economics in Bergen, where she researches the measuring of inequalities in income and what is perceived as justifiable differences in terms of inequalities in income. In addition to covering a wide field of research and publishing articles in leading scientific journals, she actively participates in social debate.
Alms' doctoral thesis "Essays in Economic Inequality" (2008) aroused much attention both in Norway and internationally. One of the essays was published in world-leading journal American Economics Review, which made her the first Nordic woman to publish a single-authored paper in that journal. The article demonstrated a new method for measuring international inequalities and criticised existing methods for major weaknesses that have led income levels in certain countries, for example China, to being overrated.
###
Our website presents the academic committee's statement, interviews, texts, pictures, etc., on the prize winners: http://www.holbergprisen.no/en
Press contacts:
Information about the prizes and the announcement:
Professor Sigmund Grnmo
Chair of the Ludvig Holberg Memorial Fund
Press contact in US:
Professor Michael Lynch
Cornell University
M: 1-607-266-7063
mel27@cornell.edu
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2013-03/tuob-blw031313.php
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